Our laboratory’s publications:
Abbas F, Becker S, Jones BW, Mure LS, Panda S, Hanneken A, Vinberg F. Revival of light signalling in the postmortem mouse and human retina. Nature. 2022 Jun;606(7913):351-357. doi: 10.1038/s41586-022-04709-x. Epub 2022 May 11. PubMed PMID: 35545677.
Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 Dec;297(6):101401. doi: 10.1016/j.jbc.2021.101401. Epub 2021 Nov 11. PubMed PMID: 34774799; PubMed Central PMCID: PMC8665362.
Abbas F, Vinberg F. Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans. Front Cell Neurosci. 2021;15:662453. doi: 10.3389/fncel.2021.662453. eCollection 2021. Review. PubMed PMID: 33867944; PubMed Central PMCID: PMC8046925.
Becker S, Carroll LS, Vinberg F. Diabetic photoreceptors: Mechanisms underlying changes in structure and function. Vis Neurosci. 2020 Oct 6;37:E008. doi: 10.1017/S0952523820000097. Review. PubMed PMID: 33019947; PubMed Central PMCID: PMC8694110.
Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9. doi: 10.7554/eLife.59422. PubMed PMID: 32960171; PubMed Central PMCID: PMC7529457.
Becker S, Carroll LS, Vinberg F. Rod phototransduction and light signal transmission during type 2 diabetes. BMJ Open Diabetes Res Care. 2020 Aug;8(1). doi: 10.1136/bmjdrc-2020-001571. PubMed PMID: 32784250; PubMed Central PMCID: PMC7418690.
Hutto RA, Bisbach CM, Abbas F, Brock DC, Cleghorn WM, Parker ED, Bauer BH, Ge W, Vinberg F, Hurley JB, Brockerhoff SE. Increasing Ca2+ in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Cell Death Differ. 2020 Mar;27(3):1067-1085. doi: 10.1038/s41418-019-0398-2. Epub 2019 Aug 2. PubMed PMID: 31371786; PubMed Central PMCID: PMC7206026.
Mure LS, Vinberg F, Hanneken A, Panda S. Functional diversity of human intrinsically photosensitive retinal ganglion cells. Science. 2019 Dec 6;366(6470):1251-1255. doi: 10.1126/science.aaz0898. PubMed PMID: 31806815; PubMed Central PMCID: PMC7120228.
Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23. PubMed PMID: 31121099; PubMed Central PMCID: PMC6662988.
Frans’ postdoctoral research publications:
Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 Sep 15;416:100-108. doi: 10.1016/j.neuroscience.2019.07.047. Epub 2019 Aug 7. PubMed PMID: 31400484; PubMed Central PMCID: PMC6815255.
Vinberg F, Chen J, Kefalov VJ. Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res. 2018 Nov;67:87-101. doi: 10.1016/j.preteyeres.2018.06.001. Epub 2018 Jun 6. Review. PubMed PMID: 29883715; PubMed Central PMCID: PMC6235702.
Vinberg F, Kefalov VJ. Investigating the Ca2+-dependent and Ca2+-independent mechanisms for mammalian cone light adaptation. Sci Rep. 2018 Oct 26;8(1):15864. doi: 10.1038/s41598-018-34073-8. PubMed PMID: 30367097; PubMed Central PMCID: PMC6203770.
Vinberg F, Peshenko IV, Chen J, Dizhoor AM, Kefalov VJ. Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. J Biol Chem. 2018 May 11;293(19):7457-7465. doi: 10.1074/jbc.RA117.001574. Epub 2018 Mar 16. PubMed PMID: 29549122; PubMed Central PMCID: PMC5949989.
Vinberg F, Wang T, De Maria A, Zhao H, Bassnett S, Chen J, Kefalov VJ. The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision. Elife. 2017 Jun 26;6. doi: 10.7554/eLife.24550. PubMed PMID: 28650316; PubMed Central PMCID: PMC5515578.
Sakurai K, Vinberg F, Wang T, Chen J, Kefalov VJ. The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction. Sci Rep. 2016 Sep 1;6:32521. doi: 10.1038/srep32521. PubMed PMID: 27580676; PubMed Central PMCID: PMC5007492.
Vinberg F, Wang T, Molday RS, Chen J, Kefalov VJ. A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet. 2015 Oct 15;24(20):5915-29. doi: 10.1093/hmg/ddv319. Epub 2015 Aug 5. PubMed PMID: 26246500; PubMed Central PMCID: PMC4581614.
Vinberg F, Turunen TT, Heikkinen H, Pitkänen M, Koskelainen A. A novel Ca2+-feedback mechanism extends the operating range of mammalian rods to brighter light. J Gen Physiol. 2015 Oct;146(4):307-21. doi: 10.1085/jgp.201511412. PubMed PMID: 26415569; PubMed Central PMCID: PMC4586592.
Vinberg F, Kefalov V. Simultaneous ex vivo functional testing of two retinas by in vivo electroretinogram system. J Vis Exp. 2015 May 6;(99):e52855. doi: 10.3791/52855. PubMed PMID: 25992809; PubMed Central PMCID: PMC4469378.
Zhou Z, Vinberg F, Schottler F, Doggett TA, Kefalov VJ, Ferguson TA. Autophagy supports color vision. Autophagy. 2015;11(10):1821-32. doi: 10.1080/15548627.2015.1084456. PubMed PMID: 26292183; PubMed Central PMCID: PMC4824586.
Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5445-54. doi: 10.1073/pnas.1410162111. Epub 2014 Dec 1. PubMed PMID: 25453064; PubMed Central PMCID: PMC4273384.
Vinberg F, Kolesnikov AV, Kefalov VJ. Ex vivo ERG analysis of photoreceptors using an in vivo ERG system. Vision Res. 2014 Aug;101:108-17. doi: 10.1016/j.visres.2014.06.003. Epub 2014 Jun 21. PubMed PMID: 24959652; PubMed Central PMCID: PMC4149224.
Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J. 2014 Aug;28(8):3780-91. doi: 10.1096/fj.14-254292. Epub 2014 May 8. PubMed PMID: 24812086; PubMed Central PMCID: PMC4101655.
Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1339-47. doi: 10.1167/iovs.13-13564. PubMed PMID: 24526444; PubMed Central PMCID: PMC3945901.
Frans’ graduate research publications:
Heikkinen H, Vinberg F, Pitkänen M, Kommonen B, Koskelainen A. Flash responses of mouse rod photoreceptors in the isolated retina and corneal electroretinogram: comparison of gain and kinetics. Invest Ophthalmol Vis Sci. 2012 Aug 17;53(9):5653-64. doi: 10.1167/iovs.12-9678. PubMed PMID: 22743325.
Heikkinen H, Vinberg F, Nymark S, Koskelainen A. Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. J Neurophysiol. 2011 May;105(5):2309-18. doi: 10.1152/jn.00536.2010. Epub 2011 Mar 9. PubMed PMID: 21389302.
Vinberg F, Koskelainen A. Calcium sets the physiological value of the dominant time constant of saturated mouse rod photoresponse recovery. PLoS One. 2010 Sep 27;5(9):e13025. doi: 10.1371/journal.pone.0013025. PubMed PMID: 20885958; PubMed Central PMCID: PMC2946398.
Vinberg FJ, Strandman S, Koskelainen A. Origin of the fast negative ERG component from isolated aspartate-treated mouse retina. J Vis. 2009 Nov 17;9(12):9.1-17. doi: 10.1167/9.12.9. PubMed PMID: 20053100.